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Article

Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.

Immunity - 1 Feb 1996

Löffert D, Ehlich A, Müller W, Rajewsky K

Abstract excerpt

Allelic exclusion at the IgH locus was examined in B lineage cells of wild-type mice and mice unable to express the surrogate light chain molecule lambda 5 using a single-cell PCR approach. By analyzing B precursor cells containing two VHDHJH rearrangements, we found that in wild-type animals, cells are allelically excluded as soon as mu chains are expressed. Furthermore, we provide evidence that in cells...

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Identifiers

PMID: 8624804
DOI: 10.1016/s1074-7613(00)80678-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.PMID 8624804Read ↗

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