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Article

Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2000

Xu S, Wong S C, Lam K P

Abstract excerpt

The pre-B cell receptor (pre-BCR) and the BCR are required for B lymphopoiesis and for the allelic exclusion of Ig genes. Mice lacking B cell linker (BLNK) protein that is a component of the BCR signaling pathway have impaired B cell development. In this report, we show that allelic exclusion is intact in BLNK(-/-) mice harboring a V(H)12 transgene. This differs from mice lacking the tyrosine kinase Syk that is...

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Share to B-Lymphocytes
Share to CD5 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

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Source

Identifiers

PMID: 11035046
DOI: 10.4049/jimmunol.165.8.4153

Genes

BLNK
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells.PMID 11035046Read ↗

An Essential Role for BLNK in Human B Cell DevelopmentSemantic proximity Read ↗

Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.Semantic proximity Read ↗

Enteroviral Infection in a Patient with BLNK Adaptor Protein Deficiency.Semantic proximity Read ↗

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.Semantic proximity Read ↗

Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.Semantic proximity Read ↗

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.Semantic proximity Read ↗

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.Semantic proximity Read ↗

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.Semantic proximity Read ↗

Highly restricted usage of Ig H chain VH14 family gene segments in Slp65-deficient pre-B cell leukemia in mice.Semantic proximity Read ↗

The BLNK adaptor protein has a nonredundant role in human B-cell differentiation.Semantic proximity Read ↗

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.Semantic proximity Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

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