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Article

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2002

Shimizu Takeyuki, Mundt Cornelia, Licence Steve, Melchers Fritz, Mårtensson Inga-Lill

Abstract excerpt

At the precursor B cell stage during bone marrow B cell development, Ig muH chain associates with surrogate L (SL) chain, which is encoded by the three genes VpreB1, VpreB2, and lambda 5, to form the pre-B cell receptor (pre-BCR). Surface expression of the pre-BCR is believed to signal both proliferation and allelic exclusion of the IgH locus. Mice which lack either VpreB1/VpreB2 or lambda 5 show a lack of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12055243
DOI: 10.4049/jimmunol.168.12.6286

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.PMID 12055243Read ↗

Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.Semantic proximity Read ↗

Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.Semantic proximity Read ↗

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.Semantic proximity Read ↗

Control of the sizes and contents of precursor B cell repertoires in bone marrow.Semantic proximity Read ↗

Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells.Semantic proximity Read ↗

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.Semantic proximity Read ↗

Cutting edge: B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells.Semantic proximity Read ↗

The Ig heavy chain protein but not its message controls early B cell development.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci.Semantic proximity Read ↗

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Semantic proximity Read ↗

Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression.Semantic proximity Read ↗

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