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Article

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.

The Journal of experimental medicine - 16 Jan 2009

Li Fubin, Eckhardt Laurel A

Abstract excerpt

The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine E mu's subsequent functions, we created an Igh allele with assembled V(H) gene but with E mu removed. In mice homozygous for this E mu-deficient allele, B cell development was normal and indistinguishable from that of mice with the same V(H) knockin and E mu intact. In mice heterozygous...

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Share to B-Lymphocyte Subsets
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Immunoglobulin kappa-Chains

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Share to Receptors, Antigen, B-Cell

Source

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Identifiers

PMID: 19114667
DOI: 10.1084/jem.20081202
PMCID: PMC2626684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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