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Article

Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas.

Molecular and cellular biology - 1 Mar 1996

D'Abaco G M, Whitehead R H, Burgess A W

Abstract excerpt

Colon carcinomas appear to arise from the cumulative effect of mutations to several genes (APC, DCC, p53, ras, hMLH1, and hMSH2). By using novel colonic epithelial cell lines derived from the Immorto mouse, named the YAMC (young adult mouse colon) cell line, and an Immorto-Min mouse hybrid, named the IMCE (Immorto-Min colonic epithelial) cell line, carrying the Apc min mutation, we investigated the effect of an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8622690
DOI: 10.1128/MCB.16.3.884
PMCID: PMC231069

Genes

APC
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas.PMID 8622690Read ↗

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