Article
Multistep carcinogenesis of the colon in Apc(Min/+) mouse.
Cancer science - 1 Jan 2007
Yamada Yasuhiro, Mori Hideki
Abstract excerpt
Colon cancer arises through different histological stages representing different genetic and epigenetic alterations. The Apc(Min/+) mouse has a point mutation at the Apc gene, and it is considered to be a model for human familial adenomatous polyposis. Our previous studies have revealed the presence of a number of intramucosal microadenomas in the colons of Apc(Min/+) mice, in which only a few macroscopic tumors...
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