Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.

Cancer science - 1 Jan 2007

Yamada Yasuhiro, Mori Hideki

Abstract excerpt

Colon cancer arises through different histological stages representing different genetic and epigenetic alterations. The Apc(Min/+) mouse has a point mutation at the Apc gene, and it is considered to be a model for human familial adenomatous polyposis. Our previous studies have revealed the presence of a number of intramucosal microadenomas in the colons of Apc(Min/+) mice, in which only a few macroscopic tumors...

Topics

Animals
Colonic Neoplasms
Disease Models, Animal
Disease Progression
Epigenesis, Genetic
Genes, APC
Humans
Mice
Mice, Mutant Strains
Models, Biological
Mutation
Precancerous Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 17052257
DOI: 10.1111/j.1349-7006.2006.00348.x
PMCID: PMC11159231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.PMID 17052257Read ↗

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Semantic proximity Read ↗

APC and its modifiers in colon cancer.Semantic proximity Read ↗

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ MiceSemantic proximity Read ↗

Emergent issues in the genetics of intestinal neoplasia.Semantic proximity Read ↗

The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.Semantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Semantic proximity Read ↗

Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.