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Article

Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis.

Cancer science - 1 May 2008

Tanaka Miwa, Jin Guang, Yamazaki Yukari, Takahara Tomoko, Takuwa Miki, Nakamura Takuro

Abstract excerpt

The mutation of Apc is an important early genetic event in colon carcinogenesis. However, it remains to be clarified what kinds of cooperative genes are required for complete carcinogenesis. To identify cooperative genes for the Apc(Min) mutation the authors carried out retroviral insertional mutagenesis (RIM) using Min mouse-derived IMCE colon epithelial cells. Anchorage-independent transformed colonies were...

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Source

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Identifiers

PMID: 18294281
DOI: 10.1111/j.1349-7006.2008.00757.x
PMCID: PMC11158175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis.PMID 18294281Read ↗

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