Article
Human leukocyte antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patients.
Cancer research - 15 Mar 2006
Somasundaram Rajasekharan, Swoboda Rolf, Caputo Laura, Otvos Laszlo, Weber Barbara, Volpe Patricia, van Belle Patricia, Hotz Susan, Elder David E, Marincola Francesco M, Schuchter Lynn, Guerry DuPont, Czerniecki Brian J, Herlyn Dorothee
Abstract excerpt
Mutated BRAF (BRAF(V600E)) is a potential immunotherapeutic target for melanoma because of its tumor specificity and expression in the majority of these lesions derived from different patients. BRAF(V600E) is expressed intracellularly and not on the cell surface, therefore providing a target for...
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