Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2014

van Buuren Marit M, Dijkgraaf Feline E, Linnemann Carsten, Toebes Mireille, Chang Cynthia X L, Mok Juk Yee, Nguyen Melanie, van Esch Wim J E, Kvistborg Pia, Grotenbreg Gijsbert M, Schumacher Ton N M

Abstract excerpt

Peptide-MHC (pMHC) multimers have become one of the most widely used tools to measure Ag-specific T cell responses in humans. With the aim of understanding the requirements for pMHC-based personalized immunomonitoring, in which individuals expressing subtypes of the commonly studied HLA alleles are encountered, we assessed how the ability to detect Ag-specific T cells for a given peptide is affected by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Melanoma
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Clone Cells

Share to HLA-A2 Antigen

Share to Lymphocytes, Tumor-Infiltrating

Share to Major Histocompatibility Complex

Share to Peptides

Source

Identifiers

PMID: 24342804
DOI: 10.4049/jimmunol.1301770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.PMID 24342804Read ↗

Identification of Human Antigen-Specific CD4+ Cells with Peptide-MHC Multimer Technologies.Semantic proximity Read ↗

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.Semantic proximity Read ↗

OMIP-002: Phenotypic analysis of specific human CD8+ T-cells using peptide-MHC class I multimers for any of four epitopes.Semantic proximity Read ↗

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidomeSemantic proximity Read ↗

Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.Semantic proximity Read ↗

Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.Semantic proximity Read ↗

Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.Semantic proximity Read ↗

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.Semantic proximity Read ↗

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.Semantic proximity Read ↗

High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.Semantic proximity Read ↗

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.Semantic proximity Read ↗

Systematic identification of immunodominant CD8 <sup>+</sup> T-cell responses to influenza A virus in HLA-A2 individualsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.