Article
Diversity of the fine specificity displayed by HLA-A*0201-restricted CTL specific for the immunodominant Melan-A/MART-1 antigenic peptide.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998
Valmori D, Gervois N, Rimoldi D, Fonteneau J F, Bonelo A, Liénard D, Rivoltini L, Jotereau F, Cerottini J C, Romero P
Abstract excerpt
HLA-A*0201 melanoma patients often develop a CTL response to an immunodominant peptide derived from the melanocyte lineage-specific protein Melan-A/MART-1. We have shown previously that the antigenic peptide most often involved is the decapeptide Melan-A(26-35) (EAAGIGILTV). We also observed some...
Topics
- Alleles
- Amino Acid Substitution
- Antigens, Neoplasm
- Cell Line, Transformed
- Cells, Cultured
- Gene Rearrangement, T-Lymphocyte
- HLA-A2 Antigen
- Humans
- Immunodominant Epitopes
- Lymphocytes, Tumor-Infiltrating
- MART-1 Antigen
- Melanoma
- Neoplasm Proteins