Article
Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1998
Bettinotti M P, Kim C J, Lee K H, Roden M, Cormier J N, Panelli M, Parker K K, Marincola F M
Abstract excerpt
The exclusiveness of the relationship between peptide and HLA alleles, combined with their extensive polymorphism, emphasizes the need for immunization strategies based on endogenous processing of full length proteins (containing multiple epitopic determinants) for presentation to T cells. This could allow vaccination regardless of the patient's HLA phenotype, assuming that individual molecules can be efficient T...
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