Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.

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Article

Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1998

Bettinotti M P, Kim C J, Lee K H, Roden M, Cormier J N, Panelli M, Parker K K, Marincola F M

Abstract excerpt

The exclusiveness of the relationship between peptide and HLA alleles, combined with their extensive polymorphism, emphasizes the need for immunization strategies based on endogenous processing of full length proteins (containing multiple epitopic determinants) for presentation to T cells. This c...

Topics

Alleles
Amino Acid Sequence
Antibodies, Neoplasm
Antigen Presentation
Antigens, Neoplasm
Cells, Cultured
Cytotoxicity Tests, Immunologic
Epitopes, T-Lymphocyte
Fowlpox virus
HLA-DQ Antigens
HLA-DQ alpha-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunodominant Epitopes

MART-1 Antigen

Melanoma

Molecular Sequence Data

Neoplasm Proteins

Peptide Fragments

Source

Open in PubMed

Identifiers

PMID: 9670966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9670966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.PMID 9670966Read ↗

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