Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.

doi:10.1002/ijc.2910640505

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Article

Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.

International journal of cancer - 20 Oct 1995

Spagnoli G C, Schaefer C, Willimann T E, Kocher T, Amoroso A, Juretic A, Zuber M, Luscher U, Harder F, Heberer M

Abstract excerpt

Peptide specificity of cultured tumor-infiltrating lymphocytes (TIL) was systematically investigated in a group of HLA-A2.1+ metastatic melanoma patients consecutively referred to our department for surgical treatment. Seven samples from 6 patients were studied. All surgical specimens showed evidence of gp 100, MART-1/Melan-A and Tyrosinase gene expression as detectable by reverse PCR (rPCR). Cultured TIL from 2...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Amino Acid Sequence
Antigens, Neoplasm
Base Sequence
Cell Transformation, Viral
Cytotoxicity, Immunologic
Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Granulocytes

HLA-A2 Antigen

Herpesvirus 4, Human

Humans

Isoantigens

Lymphocyte Activation

Lymphocytes, Tumor-Infiltrating

Source

Open in PubMed

Identifiers

PMID: 7591302
DOI: 10.1002/ijc.2910640505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591302-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.PMID 7591302Read ↗

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