HLA-A2 subtypes are functionally distinct in peptide binding and presentation.

doi:10.1084/jem.182.6.1847

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Article

HLA-A2 subtypes are functionally distinct in peptide binding and presentation.

The Journal of experimental medicine - 1 Dec 1995

Barouch D, Friede T, Stevanović S, Tussey L, Smith K, Rowland-Jones S, Braud V, McMichael A, Rammensee H G

Abstract excerpt

Nearly half of HLA-A2-positive individuals in African populations have a subtype of HLA-A2 other than the A*0201 allele. We have isolated the common African HLA-A2 subtype genes from Epstein-Barr virus-transformed B cell lines and have established stable class I reduced transfectants expressing t...

Topics

Alleles
Amino Acid Sequence
Antigen-Presenting Cells
HLA-A2 Antigen
Humans
Ligands
Models, Molecular
Molecular Sequence Data
Peptides
Protein Binding
T-Lymphocytes, Cytotoxic
Transfection

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