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Article

Indication for linkage of the human OB gene region with extreme obesity.

Diabetes - 1 May 1996

Clement K, Garner C, Hager J, Philippi A, LeDuc C, Carey A, Harris T J, Jury C, Cardon L R, Basdevant A, Demenais F, Guy-Grand B, North M, Froguel P

Abstract excerpt

Obesity is one of the most significant risk factors for hypertension, coronary heart disease, and NIDDM (Frayn KN, Coppack SW: Insulin resistance, adipose tissue and coronary heart disease. Clin Sci 82:1-8, 1992; Kaplan NM: The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 149:1514-1520, 1989). While family segregation, adoption, and twin studies...

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Identifiers

PMID: 8621024
DOI: 10.2337/diab.45.5.687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indication for linkage of the human OB gene region with extreme obesity.PMID 8621024Read ↗

A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.Semantic proximity Read ↗

Structural Organization and Chromosomal Assignment of the Human obese GeneSemantic proximity Read ↗

Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents.Semantic proximity Read ↗

OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas.Semantic proximity Read ↗

Markers for the gene ob and serum leptin levels in human morbid obesity.Semantic proximity Read ↗

Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.Semantic proximity Read ↗

Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.Semantic proximity Read ↗

Genomic Structure and Promoter Analysis of the Human obese GeneSemantic proximity Read ↗

A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels.Semantic proximity Read ↗

Molecular mapping of the mouse ob mutation.Semantic proximity Read ↗

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.Semantic proximity Read ↗

Obese (ob) gene defects are rare in human obesity.Semantic proximity Read ↗

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