Indication for linkage of the human OB gene region with extreme obesity.

doi:10.2337/diab.45.5.687

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Article

Indication for linkage of the human OB gene region with extreme obesity.

Diabetes - 1 May 1996

Clement K, Garner C, Hager J, Philippi A, LeDuc C, Carey A, Harris T J, Jury C, Cardon L R, Basdevant A, Demenais F, Guy-Grand B, North M, Froguel P

Abstract excerpt

Obesity is one of the most significant risk factors for hypertension, coronary heart disease, and NIDDM (Frayn KN, Coppack SW: Insulin resistance, adipose tissue and coronary heart disease. Clin Sci 82:1-8, 1992; Kaplan NM: The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyc...

Topics

Alleles
Animals
Base Sequence
Body Mass Index
Chromosome Mapping
Chromosomes, Human, Pair 7
DNA Primers
Family
Genetic Linkage
Genetic Markers
Genotype
Humans
Leptin
Linkage Disequilibrium
Mice
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8621024
DOI: 10.2337/diab.45.5.687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8621024-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Nuclear Family

Obesity, Morbid