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Article

Markers for the gene ob and serum leptin levels in human morbid obesity.

Human genetics - 1 May 1997

Oksanen L, Ohman M, Heiman M, Kainulainen K, Kaprio J, Mustajoki P, Koivisto V, Koskenvuo M, Jänne O A, Peltonen L, Kontula K

Abstract excerpt

Leptin, the product of the ob gene, reduces body fat in genetically obese animals and circulates in elevated concentrations in the blood of obese patients. Polymorphic markers situated in the proximity of the human ob gene have recently been suggested to be linked to morbid obesity. We have studied the possible association between the microsatellite markers near the ob gene and morbid obesity in 252 morbidly...

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Identifiers

PMID: 9150718
DOI: 10.1007/s004390050406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Markers for the gene ob and serum leptin levels in human morbid obesity.PMID 9150718Read ↗

OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas.Semantic proximity Read ↗

Indication for linkage of the human OB gene region with extreme obesity.Semantic proximity Read ↗

A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.Semantic proximity Read ↗

Genetic variants of the human obesity (OB) gene in subjects with and without Prader-Willi syndrome: comparison with body mass index and weight.Semantic proximity Read ↗

A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels.Semantic proximity Read ↗

Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.Semantic proximity Read ↗

Absence of mutations in the human OB gene in obese/diabetic subjects.Semantic proximity Read ↗

Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.Semantic proximity Read ↗

Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans.Semantic proximity Read ↗

Obese (ob) gene defects are rare in human obesity.Semantic proximity Read ↗

Identification of two novel missense mutations in the human OB gene.Semantic proximity Read ↗

Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene.Semantic proximity Read ↗

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