Article
A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.
Diabetologia - 1 Nov 1996
Shintani M, Ikegami H, Yamato E, Kawaguchi Y, Fujisawa T, Nakagawa Y, Hamada Y, Ueda H, Miki T, Ogihara T
Abstract excerpt
The mouse ob gene and its human homologue OB have recently been cloned. The mutations in the ob gene are known to be associated with extreme obesity. The relationship between the human OB gene and disease, however, is largely unknown due to the lack of suitable markers within or adjacent to the OB gene. To obtain informative markers, we searched for simple tandem repeat polymorphisms in the genomic sequence of...
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