Article
A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.
Diabetologia - 1 Nov 1996
Shintani M, Ikegami H, Yamato E, Kawaguchi Y, Fujisawa T, Nakagawa Y, Hamada Y, Ueda H, Miki T, Ogihara T
Abstract excerpt
The mouse ob gene and its human homologue OB have recently been cloned. The mutations in the ob gene are known to be associated with extreme obesity. The relationship between the human OB gene and disease, however, is largely unknown due to the lack of suitable markers within or adjacent to the O...
Topics
- Alleles
- Base Sequence
- Body Mass Index
- DNA Primers
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Leptin
- Male
- Microsatellite Repeats
- Obesity
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proteins