Article
Obese (ob) gene defects are rare in human obesity.
Obesity research - 1 Jan 1997
Carlsson B, Lindell K, Gabrielsson B, Karlsson C, Bjarnason R, Westphal O, Karlsson U, Sjöström L, Carlsson L M
Abstract excerpt
Our knowledge of the role of the recently cloned ob-protein (leptin) in the regulation of body fat stores is largely derived from experiments performed in mice. Different mouse models exhibit abnormalities in ob-gene expression, with extreme overexpression in mice which lack bioactive ob-protein,...
Topics
- Adipose Tissue
- Adult
- Animals
- Blotting, Northern
- Child
- Craniopharyngioma
- DNA, Complementary
- Female
- Gene Expression
- Humans
- Hypothalamus
- Leptin
- Male
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Mutation
- Obesity