Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.

doi:10.2337/diab.44.8.999

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Article

Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.

Diabetes - 1 Aug 1995

Stirling B, Cox N J, Bell G I, Hanis C L, Spielman R S, Concannon P

Abstract excerpt

Non-insulin-dependent diabetes mellitus (NIDDM) is a complex metabolic disorder with a significant genetic component. Obesity is a frequent complicating factor for NIDDM. In the mouse, a number of single gene defects that result in obesity have been described. Mutations in one of these genes, the ob gene, results in both obesity and NIDDM. Recently, the cloning of the murine ob gene and its human homologue has...

Topics

Animals
Base Sequence
Chromosomes, Artificial, Yeast
Cricetinae
DNA Primers
DNA, Satellite
Diabetes Mellitus
Diabetes Mellitus, Type 2
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Hybrid Cells

Mexican Americans

Mice

Mice, Obese

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7622007
DOI: 10.2337/diab.44.8.999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7622007-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.PMID 7622007Read ↗

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