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Article

Interaction of mutants of tissue-type plasminogen activator with liver cells: effect of domain deletions.

The Biochemical journal - 1 Feb 1996

Kuiper J, Van't Hof A, Otter M, Biessen E A, Rijken D C, van Berkel T J

Abstract excerpt

The fibrin-specific thrombolyticum tissue-type plasminogen activator (t-PA) has proven to be a potent drug in several clinical trials, but its clinical application is complicated by the rapid clearance of t-PA from the circulation. The rapid plasma clearance of t-PA results from the uptake of t-PA in the liver. t-PA consists of several domains which may be involved in the interaction with the liver. Three...

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Identifiers

PMID: 8611154
DOI: 10.1042/bj3130775
PMCID: PMC1216977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Interaction of mutants of tissue-type plasminogen activator with liver cells: effect of domain deletions.PMID 8611154Read ↗

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