Article
The role of the finger domain of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in initiation and progression of thrombolysis.
Thrombosis and haemostasis - 1 Dec 1994
Stringer H A, van Swieten P, Horrevoets A J, Smilde A, Pannekoek H
Abstract excerpt
We further investigated the role of the finger (F) and the kringle-2 (K2) domains of tissue-type plasminogen activator (t-PA) in fibrin-stimulated plasminogen activation. To that end, the action of purified (wt) t-PA or of variants lacking F (del.F) or K2 (del.K2) was assessed either in a static,...
Topics
- Fibrinolysis
- Gene Deletion
- Genetic Complementation Test
- Genetic Variation
- Humans
- Plasminogen Activator Inhibitor 1
- Protein Structure, Tertiary
- Thrombosis
- Tissue Plasminogen Activator