Article
Thrombolytic and pharmacokinetic properties of human tissue-type plasminogen activator variants, obtained by deletion and/or duplication of structural/functional domains, in a hamster pulmonary embolism model.
Thrombosis and haemostasis - 12 Feb 1991
Collen D, Lijnen H R, Vanlinthout I, Kieckens L, Nelles L, Stassen J M
Abstract excerpt
A pulmonary embolism model in hamsters was used for the quantitative evaluation of the thrombolytic and pharmacokinetic properties of variants of tissue-type plasminogen activator (t-PA). A 25 microliters 125I-fibrin labeled human plasma clot was made in vitro and injected into the jugular vein of heparinized hamsters. The extent of thrombolysis within 90 min was determined as the difference between the...
Topics
- Animals
- Chromosome Deletion
- Cricetinae
- Disease Models, Animal
- Humans
- Multigene Family
- Mutation
- Pulmonary Embolism
- Structure-Activity Relationship
- Tissue Plasminogen Activator