Article
Kringle 1 domain of human tissue-type plasminogen activator is a functional module mediating fibrinogen-stimulated plasminogenolytic activity.
Gene - 15 Mar 1990
Stern A, Weidle U H
Abstract excerpt
The functions of the finger and kringle-2 (K2) domains of human tissue-type plasminogen activator (t-PA) in mediating fibrin-stimulated plasminogenolytic activity are well documented. Contradictory results have been reported for the kringle-1 (K1) domain with respect to this property. To clarify this issue we have deleted the finger and the K2 domains of t-PA according to the exon-intron organization of the gene...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Cell Line
- Fibrinogen
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Plasminogen
- Tissue Plasminogen Activator