Article
Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor--and kringle one-domains.
Arzneimittel-Forschung - 1 Mar 1992
Emeis J J, Verheijen J H
Abstract excerpt
In a rabbit jugular vein thrombosis model, the thrombolytic properties of melanoma tissue-type plasminogen activator (mt-PA), recombinant t-PA (rt-PA), and a t-PA mutant that lacked the growth factor- and kringle one-domain (designated FK2P, as it contained the finger-, kringle two-, and protease-domain) were compared. Over the dose range tested (3.75 to 30 nmol/kg) a similar, dose-dependent, thrombolytic...
Topics
- Animals
- Fibrinolytic Agents
- Growth Substances
- In Vitro Techniques
- Jugular Veins
- Liver
- Mutation
- Rabbits
- Rats
- Recombinant Proteins
- Thrombophlebitis