Article
Fibrin affinity and clearance of t-PA deletion and substitution analogues.
Thrombosis and haemostasis - 19 Feb 1990
Johannessen M, Diness V, Pingel K, Petersen L C, Rao D, Lioubin P, O'Hara P, Mulvihill E
Abstract excerpt
To investigate structure-function relationships in tissue-type plasminogen activator (t-PA) we deleted the following domains in the heavy chain: a) The epidermal growth factor domain (t-PA del. G), b) the finger domain, and the epidermal growth factor domain (t-PA del. FG), and c) the finger, the epidermal growth factor and Kringle 1 (t-PA del. FGK1). To study specifically the function of the growth factor domain...
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