Article
Fibrin affinity and clearance of t-PA deletion and substitution analogues.
Thrombosis and haemostasis - 19 Feb 1990
Johannessen M, Diness V, Pingel K, Petersen L C, Rao D, Lioubin P, O'Hara P, Mulvihill E
Abstract excerpt
To investigate structure-function relationships in tissue-type plasminogen activator (t-PA) we deleted the following domains in the heavy chain: a) The epidermal growth factor domain (t-PA del. G), b) the finger domain, and the epidermal growth factor domain (t-PA del. FG), and c) the finger, the...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chromosome Deletion
- Enzyme-Linked Immunosorbent Assay
- Female
- Fibrin
- Fibrinolysis
- Immunosorbent Techniques
- Male
- Metabolic Clearance Rate
- Molecular Sequence Data
- Mutation
- Protein Binding
- Rabbits
- Rats
- Rats, Inbred Strains