Article
Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant.
Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 1996
Raha M, Wang G, Seidman M M, Glazer P M
Abstract excerpt
Psoralen-conjugated triple-helix-forming oligonucleotides have been used to generate site-specific mutations within mammalian cells. To investigate factors influencing the efficiency of oligonucleotide-mediated gene targeting, the processing of third-strand-directed psoralen adducts was compared...
Topics
- Base Sequence
- Cell Line
- DNA Damage
- DNA Repair
- Furocoumarins
- Genes, Suppressor
- Genetic Variation
- Humans
- Light
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- RNA, Transfer
- Transfection
- Trioxsalen