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Article

The role of DNA polymerase eta in UV mutational spectra.

DNA repair - 3 Feb 2005

Choi Jun-Hyuk, Pfeifer Gerd P

Abstract excerpt

UV irradiation generates predominantly cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts in DNA. CPDs are thought to be responsible for most of the UV-induced mutations. Thymine-thymine CPDs, and probably also CPDs containing cytosine, are replicated in vivo in a largely accurate manner by a DNA polymerase eta (Pol eta) dependent process. Pol eta is encoded by the POLH (XPV) gene in humans. In order to...

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Source

Identifiers

PMID: 15590329
DOI: 10.1016/j.dnarep.2004.09.006

Genes

POLH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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