Recombination induced by triple-helix-targeted DNA damage in mammalian cells.

doi:10.1128/MCB.16.12.6820

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Article

Recombination induced by triple-helix-targeted DNA damage in mammalian cells.

Molecular and cellular biology - 1 Dec 1996

Faruqi A F, Seidman M M, Segal D J, Carroll D, Glazer P M

Abstract excerpt

Gene therapy has been hindered by the low frequency of homologous recombination in mammalian cells. To stimulate recombination, we investigated the use of triple-helix-forming oligonucleotides (TFOs) to target DNA damage to a selected site within cells. By treating cells with TFOs linked to psora...

Topics

Animals
Cell Line
DNA Damage
Genetic Vectors
Mammals
Mutation
Nucleic Acid Conformation
Oligonucleotides
Recombination, Genetic

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