Article
Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991
Wang Y C, Maher V M, McCormick J J
Abstract excerpt
Xeroderma pigmentosum (XP) variant patients show the clinical characteristics of the disease, with increased frequencies of skin cancer, but their cells have a normal, or nearly normal, rate of nucleotide excision repair of UV-induced DNA damage and are only slightly more sensitive than normal ce...
Topics
- Bacterial Proteins
- Base Sequence
- Cell Line
- DNA Damage
- DNA Replication
- Deoxyadenine Nucleotides
- Dose-Response Relationship, Radiation
- Gene Rearrangement
- Genes, Bacterial
- Genetic Variation
- Humans
- Molecular Sequence Data
- Mutagenesis
- Plasmids
- RNA, Transfer
- Reference Values
- Transfection
- Ultraviolet Rays