Deficient DNA repair of triple helix-directed double psoralen damage in human cells.

doi:10.1016/0014-5793(95)01133-y

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Article

Deficient DNA repair of triple helix-directed double psoralen damage in human cells.

FEBS letters - 30 Oct 1995

Sandor Z, Bredberg A

Abstract excerpt

Damage induced by a single psoralen-modified triple helix-forming oligonucleotide has been reported to be efficiently repaired in human cells. In this study we investigated a set of psoralen coupled oligonucleotides introducing multiple lesions into the target DNA. A simian virus 40 (SV40) shuttl...

Topics

Base Sequence
DNA
DNA Adducts
DNA Damage
DNA Repair
Furocoumarins
Genetic Vectors
Humans
Molecular Sequence Data
Mutation
Oligonucleotides
Plasmids
Transfection
Tumor Cells, Cultured

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