Article
Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by UV light.
Molecular and cellular biology - 1 Jan 1999
McGregor W G, Wei D, Maher V M, McCormick J J
Abstract excerpt
Xeroderma pigmentosum (XP) is a rare genetic disease characterized by a greatly increased susceptibility to sunlight-induced skin cancer. Cells from the majority of patients are defective in nucleotide excision repair. However, cells from one set of patients, XP variants, exhibit normal repair bu...
Topics
- Cell Extracts
- Cell Line
- DNA Polymerase III
- DNA Repair
- DNA Replication
- HeLa Cells
- Humans
- Mutation
- Sequence Analysis, DNA
- Templates, Genetic
- Ultraviolet Rays
- Xeroderma Pigmentosum