Article
Unravelling the molecular complexity of <scp>GPCR</scp>‐mediated <scp>EGFR</scp> transactivation using functional genomics approaches
2 Sept 2013
Abstract excerpt
To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains...