Article
Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling.
The Journal of biological chemistry - 21 Mar 2003
Rathz Deborah A, Gregory Kimberly N, Fang Ying, Brown Kari M, Liggett Stephen B
Abstract excerpt
Agonist-promoted desensitization of G-protein-coupled receptors results in partial uncoupling of receptor from cognate G-protein, a process that provides for rapid adaptation to the signaling environment. This property plays important roles in physiologic and pathologic processes as well as therapeutic efficacy. However, coupling is also influenced by polymorphic variation, but the relative impact of these two...
Topics
- Adenylyl Cyclases
- Animals
- Cell Line
- Cricetinae
- Cyclic AMP
- Genotype
- Humans
- Polymorphism, Genetic
- Receptors, Adrenergic, beta-1
- Receptors, Adrenergic, beta-2