A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration.

Article

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration.

The Journal of biological chemistry - 21 Oct 1994

Green S A, Liggett S B

Abstract excerpt

beta-Adrenergic receptor (beta AR) subtypes differ not only by characteristic ligand affinities but also in the manner and extent to which they mediate agonist-promoted events such as activation of adenylyl cyclase and receptor sequestration. We utilized mutagenesis and recombinant expression in...

Topics

Adenylyl Cyclases
Amino Acid Sequence
Humans
Molecular Sequence Data
Phenotype
Proline
Receptors, Adrenergic, beta-1
Receptors, Adrenergic, beta-2
Structure-Activity Relationship

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