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Article

Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport.

The Journal of biological chemistry - 25 Jun 2010

Dong Chunmin, Yang Lingling, Zhang Xiaoping, Gu Hua, Lam May L, Claycomb William C, Xia Houhui, Wu Guangyu

Abstract excerpt

The molecular mechanism underlying the post-Golgi transport of G protein-coupled receptors (GPCRs) remains poorly understood. Here we determine the role of Rab8 GTPase, which modulates vesicular protein transport between the trans-Golgi network (TGN) and the plasma membrane, in the cell surface targeting of alpha(2B)- and beta(2)-adrenergic receptors (AR). Transient expression of GDP- and GTP-bound Rab8 mutants...

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Identifiers

PMID: 20424170
DOI: 10.1074/jbc.M109.081521
PMCID: PMC2888448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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