Article
cAMP-dependent protein kinase and protein kinase C consensus site mutations of the beta-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase.
The Journal of biological chemistry - 16 Sept 1994
Yuan N, Friedman J, Whaley B S, Clark R B
Abstract excerpt
Activation of cAMP-dependent protein kinase (cAPK) or protein kinase C (PKC) causes a rapid desensitization of beta 2-adrenergic receptor (beta AR) stimulation of adenylylcyclase in L cells, which previous studies suggest involves the cAPK/PKC consensus phosphorylation site in the third intracell...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Cricetinae
- Cyclic AMP-Dependent Protein Kinases
- Enzyme Activation
- L Cells
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Protein Kinase C
- Receptors, Adrenergic, beta
- Recombinant Proteins