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Article

Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs.

Biochemical and biophysical research communications - 22 Nov 2002

Shinoura Hitomi, Shibata Katsushi, Hirasawa Akira, Tanoue Akito, Hashimoto Keitaro, Tsujimoto Gozoh

Abstract excerpt

We have established that differing effects of alpha1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both alpha1A- and alpha1B-ARs couple to Gs, while alpha1D-AR does not. To identify the region responsible for this difference in subtype-specific Gs coupling, we constructed a series of chimeric and a set of point-mutated human alpha1A- and...

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Identifiers

PMID: 12435400
DOI: 10.1016/s0006-291x(02)02589-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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