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Article

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.

Genes & development - 15 Apr 1996

Tucker K L, Beard C, Dausmann J, Jackson-Grusby L, Laird P W, Lei H, Li E, Jaenisch R

Abstract excerpt

Embryonic stem (ES) cells homozygous for a disruption of the DNA (cytosine-5)-methyltransferase gene (Dnmt) proliferate normally with their DNA highly demethylated but die upon differentiation. Expression of the wild-type Dnmt cDNA in mutant male ES cells caused an increase in methylation of bulk DNA and of the Xist and Igf2 genes to normal levels, but did not restore the methylation of the imprinted genes H19...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8608936
DOI: 10.1101/gad.10.8.1008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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