Article
Allele-specific expression of imprinted genes in mouse migratory primordial germ cells.
Mechanisms of development - 1 Jul 2002
Szabó Piroska E, Hübner Karin, Schöler Hans, Mann Jeffrey R
Abstract excerpt
In somatic cells, imprinted genes are expressed monoallelically according to parent-of-origin. In contrast, in 11.5 days post-coitum primordial germ cells (PGCs), and later stage germ cells, these same genes are expressed biallelically, suggesting that imprints inherited from the gametes are largely erased by this stage. To determine when in germ cell development this biallelic expression phenomenon commences, we...
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