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Article

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

The EMBO journal - 1 Mar 1996

Larson R C, Lavenir I, Larson T A, Baer R, Warren A J, Wadman I, Nottage K, Rabbitts T H

Abstract excerpt

The LMO2 and TAL1 genes were first identified via chromosomal translocations and later found to encode proteins that interact during normal erythroid development. Some T cell leukaemia patients have chromosomal abnormalities involving both genes, implying that LMO2 and TAL1 act synergistically to promote tumorigenesis after their inappropriate co-expression. To test this hypothesis, transgenic mice were made...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 8605871
PMCID: PMC449997

Genes

TAL1
LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.PMID 8605871Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

Targeting LMO2 with a Peptide Aptamer Establishes a Necessary Function in Overt T-Cell NeoplasiaSemantic proximity Read ↗

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competitionSemantic proximity Read ↗

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct PathwaysSemantic proximity Read ↗

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.Semantic proximity Read ↗

Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.Semantic proximity Read ↗

Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.Semantic proximity Read ↗

TheLMO2T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell DevelopmentSemantic proximity Read ↗

T cell tumours of disparate phenotype in mice transgenic for Rbtn-2.Semantic proximity Read ↗

The <i>Lmo2</i> Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-RenewalSemantic proximity Read ↗

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.Semantic proximity Read ↗

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