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Article

Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.

Blood - 19 May 2011

Treanor Louise M, Volanakis Emmanuel J, Zhou Sheng, Lu Taihe, Sherr Charles J, Sorrentino Brian P

Abstract excerpt

LMO2 is a target of chromosomal translocations in T-cell tumors and was activated by retroviral vector insertions in T-cell tumors from X-SCID patients in gene therapy trials. To better understand the cooperating genetic events in LMO2-associated T-cell acute lymphoblastic leukemia (T-ALL), we investigated the roles of Arf tumor suppressor loss and Notch activation in murine models of transplantation. Lmo2...

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Source

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Identifiers

PMID: 21427293
DOI: 10.1182/blood-2010-09-309831
PMCID: PMC3109717

Genes

LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.PMID 21427293Read ↗

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Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

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