Article
T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
Oncogene - 19 Jul 2001
Drynan L F, Hamilton T L, Rabbitts T H
Abstract excerpt
The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development of overt tumours. RAG V-D-J recombinase can mediate genetic transposition and thus might create the secondary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.