Article
The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998
Yamada Y, Warren A J, Dobson C, Forster A, Pannell R, Rabbitts T H
Abstract excerpt
The LIM-finger protein Lmo2, which is activated in T cell leukemias by chromosomal translocations, is required for yolk sac erythropoiesis. Because Lmo2 null mutant mice die at embryonic day 9-10, it prevents an assessment of a role in other stages of hematopoiesis. We have now studied the hemato...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation
- Hematopoiesis
- Hematopoietic Stem Cells
- LIM Domain Proteins
- Leukemia, Experimental
- Leukemia, T-Cell
- Metalloproteins
- Mice
- Mutation