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Article

The <i>Lmo2</i> Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

21 Jan 2010

Abstract excerpt

The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy trials. To investigate the cellular origin of LMO2-induced leukemia, we used cell fate mapping to study mice in which the Lmo2 gene was constitutively expressed in the thymus. Lmo2 induced self-renewal of committed T cells in the mice more than 8 months before...

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Identifiers

PMID: 20093438
DOI: 10.1126/science.1182378

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