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Targeting LMO2 with a Peptide Aptamer Establishes a Necessary Function in Overt T-Cell Neoplasia

1 Jun 2009

Abstract excerpt

LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development blockade followed by clonal tumors. Therefore, LMO2 is necessary but not sufficient for overt...

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PMID: 19487290
DOI: 10.1158/0008-5472.can-08-4774

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Targeting LMO2 with a Peptide Aptamer Establishes a Necessary Function in Overt T-Cell NeoplasiaPMID 19487290Read ↗

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