Article
T cell tumours of disparate phenotype in mice transgenic for Rbtn-2.
Oncogene - 1 Dec 1994
Larson R C, Fisch P, Larson T A, Lavenir I, Langford T, King G, Rabbitts T H
Abstract excerpt
RBTN2 is a LIM domain protein which can be activated by the translocation t(11;14)(p13;q11) in childhood T cell acute leukaemia. Transgenic mice were examined in which rbtn2 protein is expressed in the T cell lineage. An average of 72% of these mice developed T cell tumours before 18 months of age, compared with 9% in transgenic mice expressing the related gene Rbtn-1. Rbtn2-induced tumours first appeared at 5...
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