Article
T cell tumours of disparate phenotype in mice transgenic for Rbtn-2.
Oncogene - 1 Dec 1994
Larson R C, Fisch P, Larson T A, Lavenir I, Langford T, King G, Rabbitts T H
Abstract excerpt
RBTN2 is a LIM domain protein which can be activated by the translocation t(11;14)(p13;q11) in childhood T cell acute leukaemia. Transgenic mice were examined in which rbtn2 protein is expressed in the T cell lineage. An average of 72% of these mice developed T cell tumours before 18 months of ag...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- CD2 Antigens
- DNA-Binding Proteins
- LIM Domain Proteins
- Lymphoma, T-Cell
- Metalloproteins
- Mice
- Mice, Transgenic
- Neoplasm Invasiveness
- Phenotype
- Translocation, Genetic