Article
Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.
Annals of neurology - 1 Mar 1996
Gearing M, Mori H, Mirra S S
Abstract excerpt
Apolipoprotein E (ApoE) epsilon4 allele, a risk factor for the development of Alzheimer's disease (AD), is associated with increased amyloid deposition. We examined cerebral cortex in 68 AD cases using antibodies to beta-amyloid (Abeta) peptides of different length (Abeta1-40 and Abeta1-42) and found that the increased plaque frequency observed with epsilon4 genotypes may be largely attributed to an increase in...
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