Article
Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.
Neuroscience letters - 17 Jan 1997
Mann D M, Iwatsubo T, Pickering-Brown S M, Owen F, Saido T C, Perry R H
Abstract excerpt
The effect of apolipoprotein E (ApoE) genotype on the deposition of amyloid beta protein (Abeta) was examined in 54 patients with Alzheimer's disease. No difference in the amount of Abeta deposited as Abeta42(43) was seen between genotype groups with no, one or two E4 alleles. However, the amount...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Brain Chemistry
- Female
- Frontal Lobe
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Peptide Fragments