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Article

Apolipoprotein E4 promotes the early deposition of Abeta42 and then Abeta40 in the elderly.

Acta neuropathologica - 1 Jul 2000

Walker L C, Pahnke J, Madauss M, Vogelgesang S, Pahnke A, Herbst E W, Stausske D, Walther R, Kessler C, Warzok R W

Abstract excerpt

The apolipoprotein Eepsilon4 allele (ApoEepsilon4) is associated with a selective increase in deposition of the 40-amino acid form of the beta-amyloid peptide (Abeta40) in endstage Alzheimer's disease. To determine how apoE genotype affects the early events in beta-amyloid pathogenesis, we analyzed the medial temporal lobes of 244 elderly persons who were not clinically demented using antibodies selective for the...

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Identifiers

PMID: 10912918
DOI: 10.1007/s004010051190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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