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Article

Heavy ion mutagenesis: linear energy transfer effects and genetic linkage.

Radiation and environmental biophysics - 1 Jun 1995

Kronenberg A, Gauny S, Criddle K, Vannais D, Ueno A, Kraemer S, Waldren C A

Abstract excerpt

We have characterized a series of 69 independent mutants at the endogenous hprt locus of human TK6 lymphoblasts and over 200 independent S1-deficient mutants of the human x hamster hybrid cell line AL arising spontaneously or following low-fluence exposures to densely ionizing Fe ions (600 MeV/amu, linear energy transfer = 190 keV/microns). We find that large deletions are common. The entire hprt gene (> 44 kb)...

Topics

Animals
Cells, Cultured
Cricetinae
Genetic Linkage
Humans
Hypoxanthine Phosphoribosyltransferase
Iron
Linear Energy Transfer
Mutation
Neoplasms, Radiation-Induced
X Chromosome

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Identifiers

PMID: 7652154
DOI: 10.1007/BF01275209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7652154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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