Article
Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells.
Experimental cell research - 15 Mar 1996
Cossette L J, Hoglinger O, Mou L, Shen S H
Abstract excerpt
PTP2C (also known as Syp/SH-PTP2/PTPlD) is a soluble protein tyrosine phosphatase present in most cell types. It interacts directly with activated PDGF receptor via its SH2 domains, which results in its phosphorylation on tyrosine residue(s). The phosphorylated PTP2C in turn binds to the SH2 doma...
Topics
- Adaptor Proteins, Signal Transducing
- Cell Line
- Cell Membrane
- Down-Regulation
- GRB2 Adaptor Protein
- Humans
- Intracellular Signaling Peptides and Proteins
- Mutation
- Phosphoproteins
- Phosphorylation
- Platelet-Derived Growth Factor
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6